Molecules Shown By NIA to extend Mouse Lifespan

A recent study by the National Institute on Aging Interventions Testing Program (ITP) finding an SGLT2 inhibitor (SGLT2i) extended the lifespan in male mice. To date, seven compounds tested by the ITP have shown a statistically significant extension of lifespan in mice: 

• Aspirin – males only (Strong et al., 2008);

• Rapamycin – males and females (females > males) (Harrison et al., 2009, Miller et al., 2011, Miller et al., 2014);

• 17-α-Estradiol – males only (Harrison et al., 2014);

• Acarbose – males and females (males > > females) (Harrison et al., 2014);

• Nordihydroguaiaretic acid (NDGA) – males only (Strong et al., 2008, Harrison et al., 2014);

• Protandim® - males only (Strong et al., 2016);

• Canagliflozin - males only (Miller et al., 2020)