Reasons to take Rapamycin
211028 - I've been using rapamycin for the past two years, I've lost about 30lbs, feel fantastic now and my bioage as measured by the Levine phenotypic calculations is about 15 years younger than my chronological age. Functionally I feel as good as I did in my 30s and I'm almost twice that age - rock climbing and whitewater kayaking as well as I've ever done it. I know of other people who have been taking rapamycin for the past 4 or 5 years and are are still finding it very helpful. I've been in discussions with rapamycin -focused geroscientists and they would like a place like this that gathers the data on human usage of rapamycin - the benefits as well as the side effects. So - I've created this new website for anyone interested in rapamycin, or who is using it and wants to share information. I've got a FAQ that includes a list of the doctors that prescribe it, how to get it and the costs, etc. Feel free to check out the site, feedback welcome. Its a work in progress and right now is in what I consider to be in "beta" test mode.
Site: https://www.rapamycin.news/
FAQ: https://www.rapamycin.news/t/rapamycin-frequently-asked-questions-faq/59
Speakers: Nir Barzilai [article] and Tim Peterson Hosts: Max Unfried and Morten Scheibye-Knudsen Rapamycin user develop diabetes. Gain weight, lose muscle, many other problems. Is used for transplant immune suppression.
From TP: I've been using rapamycin for the past two years, I've lost about 30lbs, feel fantastic now and my bioage as measured by the Levine phenotypic calculations is about 15 years younger than my chronological age. Functionally I feel as good as I did in my 30s and I'm almost twice that age - rock climbing and whitewater kayaking as well as I've ever done it. I know of other people who have been taking rapamycin for the past 4 or 5 years and are are still finding it very helpful. I've been in discussions with rapamycin -focused geroscientists and they would like a place like this that gathers the data on human usage of rapamycin - the benefits as well as the side effects. So - I've created this new website for anyone interested in rapamycin, or who is using it and wants to share information. I've got a FAQ that includes a list of the doctors that prescribe it, how to get it and the costs, etc. Feel free to check out the site, feedback welcome. It’s a work in progress and right now is in what I consider to be in "beta" test mode.
From Ken: There have been questions raised about the effects of rapamycin on glucose. I’ve been taking rapamycin for several years now (5 mg per week). I also wear a CGM. In addition to rapamycin, I take 1000 mg of metformin daily. As you can see from the chart below I don’t have any glucose problems arising from my use of rapamycin. I should also mention that I stick to a low carb diet.
From Stan: I have been taking 6-8 grams weekly skipping every 5th week or so as I understand that it stays in your system for six days. I skip a week once in awhile just to make sure. I have also found it to be a diet mimic. Been on it for over three years. Also, don't take Berberine for 4-5 days after using it.
From BC: I buy my rapamycin from indiamart.com vendors...and test it at valisure.com lab for quality. The zydus sirolimus seems good. $1.2 to $2 per mg tablet. Total cost per month $30 to $40.
From John: It has been clear for some time that sizable doses of Rapamycin, like those used to suppress immune reaction to organ transplants, can have dangerous side effects. What isn't clear that taking a smaller dose of Rapamycin once a week, as is done for anti-aging interventions, has dangerous side effects. Do you have any evidence of that? It isn't clear from the paper you link to (a) how big was the dose used on the mice as scaled to a typical human anti-aging dose, and (b) whether it was given daily or with a longer spacing. They just said the effect was dose dependent and that the side effects disappeared quickly after the doses were stopped.
More: There are no real side effects to preclude their use as anti-aging drugs today. Furthermore, the alternative to the reversible (and avoidable) side effects of rapamycin/everolimus are the irreversible (and inevitable) effects of aging: cancer, stroke, infarction, blindness and premature death. I will also discuss why it is more dangerous not to use anti-aging drugs than to use them and how rapamycin-based drug combinations have already been implemented for potential life extension in humans [ref].
Rapamycin and its analog, everolimus, are FDA approved for human use and have been used safely for decades [ref]. In 2006, it was suggested that rapamycin could be used immediately to slow down aging and all age-related diseases in humans [2], becoming an “anti-aging drug today” [3].
mTOR inhibition extends life span in multiple organisms. In mice, when metformin treatment (Met) is added to the mTOR inhibitor rapamycin (Rap), median and maximal life span is extended to a greater degree than with Rap or Met alone [ref].
From BC: Some recent discussions on twitter regarding this issue below. I think it would to try to quantify this risk in healthy humans given current data, and identify reasonable testing protocols for early ID if these issues.
https://twitter.com/mkaeberlein/status/1295164977276280832?s=19
https://twitter.com/mkaeberlein/status/1295166278932393985?s=19