More comments to take GDF-11

211225 - HOW MUCH HUMANS SHOULD TAKE: “Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy” paper in the same category as “Supraphysiological levels of GDF11 induce striated muscle atrophy”.  Both papers just prove that excess GDF11 levels are detrimental.  And what else is new with most peptides?

Also, this paper, which is on GDF11 Wikipedia, “GDF11 attenuates liver fibrosis via expansion of liver progenitor cells. The protective role of GDF11 during liver fibrosis and suggest a potential application of GDF11 for the treatment of chronic liver disease. completely contradicts the above “GDF11 inhibition of liver autophagy” paper.

And now I will add my own proof of how flawed this paper is. I’ve been doing clinical work with GDF11 in hundreds of humans and dogs, and I know first hand that the window for proper dosing of GDF11 is extremely narrow.  And the proper doses of GDF11 are infinitesimal - the average human down regulates with a mere 15,000 pg (1.5 ng) of GDF11. From a GRG member: I thought I would give a little update on any changes I have noticed since I started GDF11 injections in March, 2019. I have reduced my intake now to a miniscule 20pg/week. My total supplementation is just under 14,000 pg. So a tiny amount. I am 63 years old, 5 feet 11 (180cm) and weigh about 158 pounds (72 kg). When I started, my reaction time to a visual stimulus was about 375 milliseconds. Now it is about 220 milliseconds. Actually, I don't record that anymore as it was rather stable at that level. My blood pressure has not changed much, but is typically about 115/65 to 120/70 in the morning. My heart rate has trended down slightly from 54 to 50. The most interesting finding for me was fasting glucose. In March 2019 a typical reading was 5.3 - 5.4. Now it is a full unit lower at 4.3-4.4 mMol/L. In American terms, that went from 95 mg/dL to 77 mg/dL. Given that my diet and other supplements have remained the same, I can only attribute the change to GDF11. Perhaps this can be explained by a paper showing in a mouse model that GDF11 is essential for production and maturation of islet progenitor cells in the pancreas. A link to the paper: https://dev.biologists.org/content/131/24/6163

211225 - Asking what the proper dose of GDF11 is like asking what the proper dose of insulin is.  Like insulin, there is not set GDF11 dose - it is highly correlated with age, fitness level and weight. And like insulin, GDF11 is difficult to dose which is why you see some people have great success with it and others see detrimental effects. We start most of the 60+ crowd at 250 pg per day and then close watch key Emfit biomarkers.  Emfit all night HRV is the most important biomarker to determine when one is down regulated.  Once a person approaches down regulation (which means they have erased their GDF11 deficit), you’ll see the all night HRV graph (heart graph on Emfit) start to show signs of arrhythmia.  Other Emfit biomarkers such as pulse, BPM, ANS balance, etc. may start to trend the wrong direction also.